A New Long-acting Insulin
نویسندگان
چکیده
منابع مشابه
Insulin glargine: a long acting insulin analog.
The main goal of treatment of diabetes mellitus (DM) is to maintain long term near normoglycemia. Insulin therapy plays a pivotal role in the management of DM. Most insulin preparations and insulin delivery systems, do not mimic the physiological insulin secretion in the body, leading to impaired metabolic control and increased hypoglycemic attacks. Insulin glargine is newer, long acting insuli...
متن کاملAlbumin-insulin conjugate releasing insulin slowly under physiological conditions: a new concept for long-acting insulin.
The covalent linkage of peptides or protein drugs to human serum albumin (HSA) greatly prolongs their lifetime in vivo but is pharmacologically irrelevant when it irreversibly inactivates them. We retain drug bioactivity by synthesizing a heterobifunctional reagent (MAL-Fmoc-OSu, 9-hydroxymethyl-2-(amino-3-maleimidopropionate)-fluorene-N-hydroxysuccinimide) that generates HSA-Fmoc-insulin on co...
متن کاملLong-Acting Human Insulin Analogs
Endogenous insulin is a hormone secreted by the beta cells of the pancreatic islets of Langerhans. Insulin acts via specific membrane-bound receptors on target tissues to regulate metabolism of carbohydrates, proteins and fats. Exogenous insulin, manufactured for pharmacologic use through recombinant DNA technology using either E. coli or Saccharomyces cerevisiae is used as replacement therapy ...
متن کاملInsulin glargine: a long-acting insulin for diabetes mellitus.
Insulin glargine is a once-daily, biosynthetic, human insulin analogue. Some trials show that in patients with type 1 diabetes mellitus, insulin glargine offers an advantage in blood glucose control compared with NPH insulin. There is some evidence of decreased nocturnal and symptomatic hypoglycemia in patients receiving insulin glargine compared with those receiving NPH insulin, but there are ...
متن کاملHow long should a long acting insulin analogue be?
After the discovery of insulin in the last century, rapidly efforts were undertaken to prolong the duration of action of injected insulin, in a naïve attempt to achieve physiological insulin profiles by just one injection of insulin a day [1]. However, the insulin profile achieved by beta-cells is quite different from a continuous supply of insulin. Indeed, when reflecting on the gold standard ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1953
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4804.242